Opie has had many friends over the course of the episodes.
- Arnold Winkler: (Opie and the Spoiled Kid) and (The Haunted House)
- Arnold Bailey: (Season 7 The Andy Griffith Show)
- Jerry Parker
- Matt Merlis: (Barney Mends a Broken Heart) and (A Wife for Andy) Opie say's Matt Merlis is his best friend.
- Nat Pike: (Quiet Sam) - Four year old friend who told Opie a penny hit by lightning is worth 6 cents.
- The Wildcats: (The Keeper of the Flame) Opie's club members.
- Tommy: (The New Housekeeper) (The Manhunt)
- Tommy: (Runaway Kid) Plays cowboys with Opie and pushes the Squad Car in front of a fire hydrant.
- Trey Bowden